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Targeting Protein Degradation in Cancer Treatment

Author(s):

Imane Bjij, Ismail Hdoufane, Mahmoud Soliman, Menče Najdoska-Bogdanov and Driss Cherqaoui*   Pages 1 - 14 ( 14 )

Abstract:


The ubiquitin proteasome system (UPS) is a crucial protein degradation pathway that involves several enzymes to maintain cellular protein homeostasis. This system has emerged as a major drug target against certain types of cancer as a disruption at the cellular level of UPS enzyme components forces the transformation of normal cell into cancerous cell. Although enormous advancements have been achieved in the understanding of tumorigenesis, efficient cancer therapy remains a goal towards alleviating this serious health issue. Since UPS has become a promising target for anticancer therapies, herein we provide comprehensive review of the ubiquitin proteasome system as a significant process for protein degradation. Herein, the anti-cancer therapeutic potential of this pathway is also discussed.

Keywords:

Protein degradation, Cancer therapy, UPS, Proteasome, Mechanism of action, Fragmentation

Affiliation:

Université Cadi Ayyad, Faculté des Sciences Semlalia, Département de Chimie, Av. My Abdellah, BP2390 Marrakech, Université Cadi Ayyad, Faculté des Sciences Semlalia, Département de Chimie, Av. My Abdellah, BP2390 Marrakech, Molecular Bio-Computation & Drug Design Lab, School of Health Sciences, University of KwaZulu-Natal, Westville, Durban 4000, Institute of Chemistry, Faculty of Natural Sciences and Mathematics, Ss. Cyril and Methodius University, Skopje, Université Cadi Ayyad, Faculté des Sciences Semlalia, Département de Chimie, Av. My Abdellah, BP2390 Marrakech



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