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The Role of Heat Shock Protein -90 (HSP-90) in Inflammatory Disorders

Author(s):

Chiranjib Bhattacharjee and Lokesh Deb*   Pages 1 - 8 ( 8 )

Abstract:


In human cells, Heat Shock Protein-90 (HSP-90) is present in the cytosol, nucleoplasm, endoplasmic reticulum, and mitochondria. The eukaryotic HSP-90 is multi-functionary and essential for cell viability, signal transduction, cell-cycle control as well as transcriptional regulation. The intracellular environment does not restrict HSP-90. It has a vital role in all types of inflammatory disorders, including cancer, autoimmune diseases, infectious inflammatory conditions. Hence, pharmacological inhibition of HSP-90 is currently a choice of therapeutic target for the treatment of autoimmune diseases, cancer, and infectious diseases. Based on the biology of HSP-90, several COOH-terminal ATPase sites of HSP-90, NH2-terminal ATPase sites of HSP-90, and Histone deacetylase inhibitors evaluated and classified under various groups. For the treatment of different inflammatory disorders HSP-90 identified as a promising therapeutic target. The present review may guide researchers for evaluating the HSP-90 targeted pathway as a useful therapeutic target for inflammatory diseases, including cancers.

Keywords:

Heat shock protein-90 (HSP-90), Autoimmune diseases, Cancer, HSP inhibitor, Viral HSP-90, Fungal HSP-90

Affiliation:

Department of Pharmacology, Srikrupa Institute of pharmaceutical Sciences, Velikatta, Kondapak, Siddipet, Telangana -502277, Institute of Bioresources and Sustainable Development - Sikkim Centre (Department of Biotechnology, Government of India), 5th Mile, NH-10A, Near Metro Point, Tadong, Gangtok, Sikkim



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