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Emerging Marine Immunomodulatory Small-molecules (2010- Present)

[ Vol. 13 , Issue. 3 ]

Author(s):

Ran Li, Yu-Cheng Gu and Wen Zhang*   Pages 187 - 196 ( 10 )

Abstract:


Background: Immunomodulation-based therapy has achieved a breakthrough in the last decade, which stimulates the passion of searching for potential immunomodulatory substances in recent years.

Objective: Marine natural products are a unique source of immunomodulatory substances. This paper summarized the emerging marine natural small-molecules and related synthesized derivatives with immunomodulatory activities to provide readers an overview of these bioactive molecules and their potential in immunomodulation therapy.

Conclusion: An increasing number of immunomodulatory marine small-molecules with diverse intriguing structure-skeletons were discovered. They may serve as a basis for further studies of marine natural products for their chemistry, related mechanism of action and structure- activity relationships.

Keywords:

Marine small-molecules, immunomodulator, immunostimulant, immunosuppressant, α- GalCer, Polyketides.

Affiliation:

School of Pharmacy, Second Military Medical University, Shanghai 200433, Syngenta, Jealott’s Hill International Research Centre, Bracknell, Berkshire RG42 6EY, School of Pharmacy, Second Military Medical University, Shanghai 200433



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