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Something Old, Something New and Something Used in Alzheimer's; the Idea of Pore, Ethanol and the Use of Oocytes to Understand the Disease

[ Vol. 13 , Issue. 2 ]

Author(s):

Jorge Parodi*   Pages 105 - 109 ( 5 )

Abstract:


Background: Alzheimer's disease remains an unsolved public health problem. Recent studies shifted the focus of the pathogenesis from a neurodegenerative process to a synaptic failure, including a large group of pathologies called peptide misfolding diseases.

Objective: In this line, recent research has proposed new models to study the pathologies such as frog oocytes, revalidation of a mechanism such as the amyloid pore, and a link of moderate alcohol consumption with a reduced risk of developing neurodegenerative diseases.

Methods: We reviewed the latest publication in this field.

Conclusion: We believe, therefore, that the available data suggest an important role of the amyloid pore mechanism in the pathogenesis of the Alzheimer's disease, the use of oocytes for its study, and how a moderate consumption of ethanol could reduce the effects of amyloid aggregates.

Keywords:

Alzheimer, synapses, calcium, pore, oocytes, peptide misfolding diseases.

Affiliation:

Laboratorio de Biologia Celular y Molecular Aplicada, Facultad de Ciencias, Universidad Mayor, Sede Temuco, Temuco

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