Jorge Parodi* Pages 105 - 109 ( 5 )
Background: Alzheimer's disease remains an unsolved public health problem. Recent studies shifted the focus of the pathogenesis from a neurodegenerative process to a synaptic failure, including a large group of pathologies called peptide misfolding diseases.
Objective: In this line, recent research has proposed new models to study the pathologies such as frog oocytes, revalidation of a mechanism such as the amyloid pore, and a link of moderate alcohol consumption with a reduced risk of developing neurodegenerative diseases.
Methods: We reviewed the latest publication in this field.
Conclusion: We believe, therefore, that the available data suggest an important role of the amyloid pore mechanism in the pathogenesis of the Alzheimer's disease, the use of oocytes for its study, and how a moderate consumption of ethanol could reduce the effects of amyloid aggregates.
Alzheimer, synapses, calcium, pore, oocytes, peptide misfolding diseases.
Laboratorio de BiologÃ�Âa Celular y Molecular Aplicada, Facultad de Ciencias, Universidad Mayor, Sede Temuco, Temuco