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Drugs for the Treatment of Mitochondrial Diseases

[ Vol. 13 , Issue. 1 ]

Author(s):

Diego F. Gomez-Casati* and Maria V. Busi   Pages 19 - 24 ( 6 )

Abstract:


Background: Mitochondrial diseases are a complex group of pathologies caused by mutations in genes coded in the nuclear and/or the mitochondrial DNA, which fulfill their function in the organelle. The diagnosis is also complex, since it depends on the integration of biochemical, histological and imaging data.

Objective: In this paper we review the use of some of these substances and their efficacy in the treatment of these disorders.

Conclusions: Currently, there is not a fully effective treatment, however, it was demonstrated that the use of some vitamins, amino acids, antioxidants along with a proper diet and exercise have an important effect that leads to improve the overall state of patients with mitochondrial disorders.

Keywords:

Mitochondria, diseases, reactive oxygen species, mitochondrial drugs, pharmacological approaches, vitamins, antioxidants.

Affiliation:

Centro de Estudios Fotosinteticos y Bioquimicos (CEFOBI-CONICET), Universidad Nacional de Rosario, Suipacha 531, 2000, Rosario, Centro de Estudios Fotosinteticos y Bioquimicos (CEFOBI-CONICET), Universidad Nacional de Rosario, Suipacha 531, 2000, Rosario

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